Quantitative Relationships between Coronary Vascular Remodeling and the Plasma Lipid Levels in Patients with Acute Coronary Syndrome

Objective To investigate the relationships between target lesion artery remodeling and the plasma lipid levels in patients with acute coronary syndrome(ACS).Methods Intravascular ultrasound(IVUS) analyses were performed in 106 ACS patients in the process of percutaneous coronary interventions.The remodeling index(RI) was calculated as the ratio between the external elastic membrane(EEM) at lesion site and the EEM at proximal reference.The patients were divided into the positive remodeling group(RI1) and negative remodeling group(RI≤1)(69 cases vs 37 cases),and meanwhile,the old age group(older than 60 years) and non-old age group(equal or less than 60 years)(55 cases vs 51 cases).At the same time the levels of plasma triglyceride,total cholesterol,LDL cholesterol and HDL cholesterol were determined.Results There is a significantly inverse relationship between RI and age(r=-0.38,P=0.03),and a significantly direct relationship between RI and TG level(r=0.32,P=0.02).The TG level in the positive remodeling group is marked higher than in the negative group(P=0.03);In patients equal or less than 60 years a statistical correlations is not found between RI and lipid level,and there are no significant differences between positive remodeling subgroup and negative remodeling subgroup;In patients older than 60 years,RI is significantly related with LDL-C levels(r=0.53,P=0.03),the levels of TG and HDL-C in positive remodeling subgroup are statistically higher than in negative remodeling group(P=0.01,P=0.04).Conclusion The plasma lipid levels of the patients with ACS appear to have some effects on the target lesion artery remodeling.