STUDIES ON URANIUM MOBILIZATION AGENTS.VIII:NEW METHOD SYNTHSIS OF CHELATING AGENTS WITH CATECHOL RESIDUE
ZH Qin
Abstract
ZH Qin
Abstract
In further study on the synthesis of chelating agents with catechol residue,twoconvenient procedures-ethyl chloroformate method and dicyclohexylcarbodiimide(DCC)method-weredeveloped.The latter was used successfully to synthesize chelating agents with several catechol units.These compounds are more effective than compounds with only one catechol unit to detoxicate micewhich were under acute UO2(NO3)2 intoxication(LD95~100).
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In further study on the synthesis of chelating agents with catechol residue,twoconvenient procedures-ethyl chloroformate method and dicyclohexylcarbodiimide(DCC)method-weredeveloped.The latter was used successfully to synthesize chelating agents with several catechol units.These compounds are more effective than compounds with only one catechol unit to detoxicate micewhich were under acute UO2(NO3)2 intoxication(LD95~100).
Key concepts: Catechol, Chelation, Chemistry, Residue (chemistry), Ethyl chloroformate, Uranium, Combinatorial chemistry, Organic chemistry