Effects of low-frequency magnetic field on bone metabolism in hindlimb of unloaded rats

Objective To study the effects of low-frequency magnetic field(LMF) on bone metabolism in hindlimb of unloaded rats. Methods SD rats were randomly divided into three groups (9 for each):the active control (AC),the tail-suspended control (SC),and the tail-suspended group(MFC) treated with LMF (14.2 mT·0.5 h/d). The experiment lasted for 21 days. Bone biomechanical proerties,bone mineral contents and bone biochemical makers of bone metabolism were measured. Results Compared with the AC group,mineral contents and biomechanical properties of bone in SC group reduced significantly. Meanwhile,in LMF group,the biochemical makers in serum and urine were ameliorative,mechanical properties and mineral contents of bone increased significantly. NO content of femoral trunk decreased significantly. Conclusions LMF may improve the bone metabolism and bone structure,decrease bone loss,increase bone biomechanical properties and reduce the risk of fracture.