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2014•Xiandai shengwu yixue jinzhanRequires access

The Role of Geftinat in Non Small Cell Lung Cancer Induced by Autophagy

XU Zhi-hon

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Abstract

Objective: To observe The role of Geftinat in non small cell lung cancer induced by autophagy and to investigate the mechanism. Methods: 40 nude mice were randomly divided into two groups, the group with geftinat was treated by infusing the stomach with the medicine, 25mg/kg. The expression of Beclin1 and MAPLC3 were determined by immunofluorescence, RT-PCR and Western blot. Results: The Mrna and protein level of Beclin1 and MAPLC3 in the group with geftinat treating were both significant higher by immunofluorescence, RT-PCR and Western blot. Conclusion: Geftinat can inhibit the progress of non small cell lung cancer by influence autophagy.

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What this paper is about

Objective: To observe The role of Geftinat in non small cell lung cancer induced by autophagy and to investigate the mechanism. Methods: 40 nude mice were randomly divided into two groups, the group with geftinat was treated by infusing the stomach with the medicine, 25mg/kg. The expression of Beclin1 and MAPLC3 were determined by immunofluorescence, RT-PCR and Western blot. Results: The Mrna and protein level of Beclin1 and MAPLC3 in the group with geftinat treating were both significant higher by immunofluorescence, RT-PCR and Western blot. Conclusion: Geftinat can inhibit the progress of non small cell lung cancer by influence autophagy.

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Available abstract

Objective: To observe The role of Geftinat in non small cell lung cancer induced by autophagy and to investigate the mechanism. Methods: 40 nude mice were randomly divided into two groups, the group with geftinat was treated by infusing the stomach with the medicine, 25mg/kg. The expression of Beclin1 and MAPLC3 were determined by immunofluorescence, RT-PCR and Western blot. Results: The Mrna and protein level of Beclin1 and MAPLC3 in the group with geftinat treating were both significant higher by immunofluorescence, RT-PCR and Western blot. Conclusion: Geftinat can inhibit the progress of non small cell lung cancer by influence autophagy.

Key concepts: Western blot, Autophagy, Immunofluorescence, Lung cancer, Cell, Blot, Lung, Cancer research

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