Research on elastase-introduced canine bifurcation saccular aneurysm model

Objective To establish canine bifurcation saccular aneurysm models and study the causes of formation. Methods Canines were divided into 3 groups, and the ElastaseⅠwas injected into the right common carotid artery combined with of without ligating the artery to establish bifurcation saccular aneurysm models. The causes of formation were studied. The aneurysms were re-examined as well as the pathology was examined in one month. Result Pathology and angiography confirmed that the rate of aneurysm formation in the group dealt with elastase- introduce accompanied with ligating the common carotid artery was 100%, and there was no aneurysm formation despite the elasticity board destruction in the group dealt only with elastase-introduced. The aneurysm formation rate of ligating group was 42.8%. Conclusion Elastase-introduced canine bifurcation saccular aneurysm model can be created repeatedly and stably. The change of homodynamic is the main reason of the formation of aneurysm, and this kind of aneurysm model with the appropriate shape and pathological characteristics is an ideal aneurysm model.