Relationship between white blood cell count and acute coronary syndrome

Objective To explore the correlation between levels of serum lipid, white blood cell (WBC) count and occurrence, development of acute coronary syndrome. Methods WBC count and levels of serum lipid were measured and compared in patients with acute coronary syndrome (ACS) , patients with stable angina pectoris (SAP) and controls. 67 patients with coronary atherosclerotic heart disease (CAHD) underwent quantitative angio-graphic assessment. The difference of WBC count and levels of serum lipid in patients with single coronary artery pathological changes were compared with those in patients with multiple coronary artery pathological changes. Results WBC count and serum concentrations of TC, TG, LDL-C in the ACS group were significantly higher than those in the SAP and control groups, respectively (P0.05), but HDL-C was significantly lower than that in the SAP and control groups (P0.05). Linear correlation analysis revealed that WBC count were positively associ-ated with serum concentrations of TC, TG, LDL-C, but it was negative associated with serum HDL-C. WBC count in the multiple coronary artery pathological changes group was significantly higher than that in other groups (P 0.05). Conclusion WBC count not only plays an important role in the occurrence and development of ACS, but also is associated with extent and severity of coronary artery disease. It can be used as a simple, inexpensive and readily available marker for evaluating atherosclerotic plaque destabilization.