Detection on serum thrombopoietin levels in patients with Hepatitis B cirrhosis and it′s clinic significance

Objective To assess the change of serum thrombopoietin(TPO) level in patients with Hepatitis B cirrhosis.In order to make clear the reason ofplatelet decreaced in patients with Hepatitis B cirrhosi.Methods Selected 40 cases of Hepatitis B cirrhosis patients(Chi1d-Pugh A,15cases;Child-Pugh B,15 cases;Child-Pugh C,10 cases) as experimental group and 20 healthy volunteers as control group.Serum TPO level was detected by ELISA(enzyme linked immunosorbent assay).Meanwhile,routine blood tests,serum levels of ALB,TBIL and PTA were tested.Spleen color Doppler ultrasound was measured by the same doctor under the same conditions.Results In cirrhosis group PLT was lower than that of healthy controls,while the spleen thickness was higher than those in the control group,the differences were statistically significant(P0.05).No significant difference was noted in serum TPO level between the control group and the cirrhosis group(P0.05).The PLT of class A,B,C groups were lower than those of healthy controls.The spleen thickness of class A were higher than those in the control group.The serum TPO levels of class B and C were lower than those of class A and the healthy control group.The TPO and PLT of the class A were higher than those of class B,C.The spleen thickness of class A was lower than those of class B,C,all differences were statistically significant(P0.05).Overall,TPO and PLT,ALB,PTA was positively correlated with the decline in liver function(r=0.498,0.619,0.766,P0.01).TPO was negatively correlated with TBIL.Spleen thickness was negatively correlated with PLT(r=-0.587,P0.05).Conclusion Reduction in the level of serum TPO and spleen enlargement may be the main reason for thrombocytopenia.Serum TPO can be used as parameters for evaluation of liver function.