2010•Zhongguo yiyuan yongyao pingjia yu fenxiRequires access

Mirtazapine versus Clomipramine for Major Depressive Disorder

Lingjun Wang

Abstract

OBJECTIVE: To evaluate the clinical efficacy and safety of mirtazapine versus clomipramine in the treatment of major depressive disorder. METHODS: 72 patients with major depressive disorder were randomly assigned to receive either mirtazapine or clomipramine for 12 weeks. The clinical efficacy and safety were evaluated with HAMD,HAMA,CGI - SI and TESS at 0,1,2,4,8 and 12 weeks. RESULTS: The total response rate was 81% for mirtazapine - treated group versus 56% for clomipramine - treated group; however mirtazapine took effect more quickly. There were significant differences in clinical effects and side reactions between the two groups ( P 0. 05). CONCLUSION: Mirtazapine is effective,safe and well - tolerated for patients with major depressive disorders.

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Key concepts: Mirtazapine, Clomipramine, Hamd, Major depressive disorder, Medicine, Antidepressant, Psychology, Anesthesia