Monitoring Immunology Index CD4 and CD8 in Drug Users with HIV or Tuberculosis

Objective To estimate the immunologic variation,monitoring the immunology index CD4 and CD8 in drug users with HIV or tuberculosis. Methods Flow cytometer(FCM) was adopted to determine CD3+,CD3+CD4+,CD3+CD8+ percentage,then calculate CD3+CD4+/ CD3+CD8+ ratio,between different groups of drug users and normal persons. Results There were differences of statistical significance in cell counts of CD3+,CD3+CD4+,and CD3+CD8+ among persons with 9 HIV, 5 TB,40 drug users of good health,40 normal persons,F test(P0.05,F=46.05,63.13,92.51,107.29).CD3+CD4+/ CD3+CD8+ ratio(P0.01) in persons with HIV was lower than in TB and in the control. Conclusion The detection of percentage of CD4 cells and CD4/CD8 ratio may be important in evaluating immune condition,progression and prognosis of patients with HIV or TB infection.Moreover,it can be presumed that polyinfection with HIV and TB may hurt the patient's immune function more seriously.