Effects of Docetaxel Plus Oxaliplatin Regimen Vs.Vinorelbine Plus Oxaliplatin Regimen on Senile Advanced Non-Small Cell Lung Cancer

Objective To compare the effect and safety of Docetaxel + Oxaliplatin regimen vs.Vinorelbine + Oxaliplatin regimen in the treatment of senile advanced non-small cell lung cancer(NSCLC).Methods Total of 45 elderly patients(age65) with advanced NSCLC diagnosed by pathology examination were randomly divided into Docetaxel+Oxaliplatin(DO) regimen gorup and Vinorelbine+Oxaliplatin(NO) regimen group in a rate of 1∶1,24 patients in DO group and 21 patients in NO group.The DO group received Oxaliplatin 130 mg/m2,iv drip,2 hours,d1,and Docetaxel 75 mg/m2,iv drip,3 hours,d2;while the NO group received Vinorelbine 25 mg/m2,iv drip,1/2 hours,d1,8,and Oxaliplatin used as DO group.Every patient was repeated every 3 weeks and was given 3 cycles.The efficacy and toxicity was then evaluated.Results Twenty four cases could be evaluated in the DO group and 21 cases in the NO group.In DO group,the overall response rate was 54.17%(13/24) and 52.38% in NO group(11/21).There was no statistically difference between the two groups regarding clinical result.The nausea and vomiting reaction and the decrease of hemoglobin and neurotoxicity were more in NO group.Conclusion The efficacy is similar for 2 regimens in the treatment of senile advanced NSCLC.DO project is relatively well tolerated and better chemotherapy method.