2004•Zhejiang Medical JournalRequires access

The effects of dexamethasone on liver superoxide dismutase, malondialdehyde in rats with chronic hypoxia

Liangxing Wang

Abstract

Objective To investigate the changes of liver superoxide dismutase (SOD) and malondialdehyde (MDA) in rats with chronic hypoxia, and the protective effects of dexamethasone. Methods The animal model of chronic hypoxia and hypercapnia with pulmonary hypertension was induced in rats. SOD and MDA in liver tissue were measured. Results The SOD level was significantly lower and the MDA content was markedly higher in hypoxic rats than those in normal animals. Dexamethasone administrations decreased MDA content and increased SOD level in the rats with chronic hypoxia. Conclusion Chronic hypoxia increases liver lipid peroxidation of the rats and dexamethasone has a protection effect on lipid peroxidative injury.

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Key concepts: Malondialdehyde, Superoxide dismutase, Hypoxia (environmental), Lipid peroxidation, Medicine, Dexamethasone, Internal medicine, Endocrinology