Expression of Proliferating Cell Nuclear Antiogen(PCNA) in left Ventricle Myocardium in Spontaneously Hypertensive Rats and Effects of Imidapril and Irbesartan

Objective To study the expression of PCNA in left ventricle myocardium in spontaneously hypertensive rats(SHR) and the inhibiting effect of imidapril and irbesartan on the expression. Methods Thirty 13-week SHR were randomly divided into three groups: SHR positive control group, imidapril treatment group(3 mg·kg -1 ·d -1 ), irbesartan treating group(50·mg·kg -1 ·d -1 ), Ten Wistar-Kyoto rats were selected as normal control group. Blood pressure were monitoring periodically. After 14 weeks, left ventricle weight(LVW) and thickness, LVW/BW and left ventricle thickness/BW were measured and calculated. PCNA were detected by immunohistochemical study. Results Blood pressure and LVW/BW, left ventricle thickness/BW in imidapril group and irbesartan group were lower than those of SHR group. Myocardial PCNA expression in SHR group was highest among the four groups, while in WKY group was the lowest, PCNA expression in imidapril group was lower than in irbesartan group. Conclusions Imidapril and irbesartan inhibit remodeling of left ventricle which is associated with the decreases in PCNA expression of left ventricle myocardium in SHR.