Study on the phenotype in the metabolic polymorphism of dextromethorphan in Han, Urghur, Hasake nationalities

Objective To study the metabolic polymotphism of dextromethorphan in Chinese population of Han, Urghur, Hasake nationalities. Methods Three hundred eighty four healthy volunteers were into 3 groups (Han, Urghur and Hasake groups). All volunteer' s urine samples within 8 h after a single oral dextromethorphan dose of 30 mg were collected. The concentration of dextromethorphan and dextrophan were measured by HPLC with fluorescence dedector. The metabolic ratio (MR) of the two metabolites was used to the classification of metabolic polymorphism of dextromethorphan in the three nationalities. Results The incidences of poor metabolizers of dextromethorphan in Han, Urghur and Hasake nationalities is 0.76%,8.09%, 1.72%, respectively. Conclusion The incidence of poor metabolizers between Han and Urghur populations shown significant statistical differences (P 0.01), and the incidence of poor metabolizers between Hasake and Urghur populations also shown statistical differences (P0.05), but no statistical difference in the incidence of poor metabolizers between Han and Hasake populations(P0.05).