The diction and clinical significance of fms-related tyrosine Kinase 3(FLT3) in acute myeloid leukemia

Objective To explore the expression of fms-related tyrosine Kinase 3(FLT3) in acute myeloid leukemia(AML).Methods AML patients with normal karyotype were 20 cases,the abnormal karyotype were 30 cases.Aspiration bone marrow 3ml before themotherapy respectively,to detect the FLT3 expression in leukemia cells with polyenzyme chain react(PCR).Results The FLT3 expression rate in AML patients with normal karyotype is 5.0%,and 26.7% is in AML Patients with abnormal karyotype,and 33.3% is in AML patients with refractory-relapse,and 4.5% is in AML patients with continue remission.The FLT3 expression rate is connection with high leukemia cells percentage in bone marroal and high blood cells count in peripheral blood,and is not connection with Franch America British(FAB) classification.The free-disease survival(FDS)and overall survived(OS) are shorter in FLT3 expression AML patients than in not FLT3 expression AML patients.There is a statistical significance between the former and the latter(P0.05).Conclusion FLT3 is a kind of danger factor in the AML patients with normal karyotype,and to guild clinical individual treatinent.