Study on the relationship between different iodine concentration and brain neurotransmitter and enzyme activity

Objective To study the relationship between different iodine concentration and brain development by measuring the neurotransmitter concentration and enzyme activity.Methods One-month weaned Wistar rats were divided into four groups,low iodine group;normal iodine group;ten-fold high iodine;fifty-fold high iodine;and fed with water of different iodine concentration by adding potassium iodide respectively.Rats mate randomly after three months.The baby rats were sacrificed after 28 days,then weigh brains and test the NO and the activity of NOS,MAO and ChE.Results Compared with the normal iodine group,the weight of brain in other groups are lower(P0.05 or P0.01),and the low iodine group is prominent;the content of protein in 20% brain decreased in low iodine group(P0.01);in low iodine group,MAO increased(P0.01),and ChE decreased(P0.01);in fifty-fold high iodine group,MAO increased(P0.01 or P0.05).Conclusions Both iodine deficiency and iodine excess can affect the neurotransmitter and the related enzyme activity.However,the iodine deficiency is more serious than the iodine excess.