The Combination of Inhaled Budesonide/Formoterol and Ambroxol in Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Objective To investigate the effect of combination therapy with inhaled budesonide /formoterol and ambroxol on the acute exacerbations of chronic obstructive pulmonary disease(AECOPD).Methods 84 subjects with AECOPD were randomly divided into 3 groups:the control group(C group, n=28),the Budesonide/ formoterol group(B group,n=28),and the Budesonide/ formoterol and ambroxol group(A group,n=28).Compare the difference of 3 groups at the pulmonary function(FEV_1,FEV_1%、FEV_1/FVC) and the scores of SGRQ before and after the therapy.Results The pulmonary function and the scores of SGRQ in 3 groups after the therapy were improved in evidence(P0.05).Compared with control group,significantly greater improvements were seen in B group and A group(P0.05).And A group were slightly better than B group(P0.05).Conclusions This study demonstrated that combination treatment with budesonide/formoterol plus ambroxol is an effective methods in the management of AECOPD.