Drug Resistance and Pathogens in Senile Patients With Lower Respiratory Tract Infection

Objective To acquaint the pathogens distribution and their antibiotic resistance in senile patients with lower respiratory tract infection with the purpose of providing practical evidence for clinical diagnosis and medicine-taking. Methods We analyzed the distribution and resistance of the pathogenic bacteria isolated from 645 sputa samples of senile patients with lower respiratory tract infection from Jan 2006 to May 2006. Results In a total of 401 strains of bacteria included 288 (71.82) of Gram-negative.bacilli were composed pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae , acinerobacter baumannii, stenotrophomonas maltophilia. ESBLs positive rates of Escherichiacoli, Klebsiella pneumoniae were 55.9% and 60.7% respectively. There are 59 strains (14.71%) among which the Staphyloccocus aureus Rosenbach and coagulative ferment negative staphylococci are the predominant. There are 54 strains of fungi among which the candida albicans was the most predominant. The result of drug sensitive test showed that there were high rates of drug resistance in most bacteria strains, but there were different drug resistance rates to different antibiotics. Conclusion The Gram-negative bacilli were the major pathogens isolated from senile patients with lower respiratory tract infection. The emergence of drug resistance is a serious problem and the drug sensitivity test results are significant in proper selection of antibiotics.