Comparison of effects of several anesthetic in rabbit spinal surgery

Objective To observe the anesthetic effects of urethane,pentobarbital sodium,ketamine and ketamine + diazepam + lidocaine in rabbit spinal surgery.Method To inject anesthetics by rabbits' ear vein slowly,then underwent spinal surgery.The urethane group:20% urethane 1 g/kg,the sodium pentobarbital group:3% sodium pentobarbital 30 mg/kg,the ketamine group:1% ketamine 40 mg/kg,the ketamine + diazepam + lidocaine group:1% ketamine 40 mg/kg + diazepam 2 mg/kg,then local instillation 2% lidocaine 1 ml after into the spinal canal.Results As compared with the ketamine group and the ketamine +diazepam + lidocaine group,the duration of anesthesia was significantly shorter(P0.05).And it was longer,as compared with the urethane group and the ketamine + diazepam + lidocaine group or the sodium pentobarbital group and the ketamine + diazepam + lidocaine group (P0.05).And the mortality during anesthesia and postoperative paralysis rate increased(P0.05),as compared with the pentobarbital sodium group and the ketamine + diazepam + lidocaine group.Then they were significantly higher in the mortality during anesthesia,postoperative mortality,postoperative paralysis and postoperative abdominal swelling rate(P0.05),as compared with the urethane group and the ketamine +diazepam + lidocaine group.Conclusion It is effective,safe and reliable for the anesthesia with injection of ketamine (40 mg/kg) and diazepam (2 mg/kg) by rabbits' ear vein slowly,then local instillation 2% lidocaine 1 ml after into the spinal canal in the rabbit spinal surgery.