Influence and curative effect observation of bifid triple viable capsules on plasma inflammatory cytokines of patients with liver cirrhosis spontaneous bacterial peritonitis(SBP)

Objective To discuss influence and curative effect observation of bifid triple viable capsules on plasma inflammatory cytokines of patients with liver cirrhosis spontaneous bacterial peritonitis(SBP). Methods A total of 84 cases of patients with liver cirrhosis SBP after suffering hepatitis B were selected, and were divided into observation group and control group with 42 cases of patients in each group. The patients in two groups were given routine medical treatment, such as routine liver protection, diuretic decreasing portal vein pressure, antibiotics, supplement of protein, nutrition support and etc. The patients in observation group were additionally given 420 mg Bifid Triple Viable Capsules per time, three times a day for 4 weeks. The changes of serum hs-CRP and TNF-α levels of patients in two groups before and after medical treatment were tested, and the clinical curative effect and adverse reaction was compared as well.Results After 4 weeks' medical treatment, serum hs-CRP and TNF-α levels of patients in two groups obviously declined(P 0.05 or P 0.01), and the declining rate of patients in observation group was much higher than that in control group(P0.05). Meanwhile, the total clinical efficiency of patients in observation group was 92.86%, which was much higher than that in control group(76.19%)(χ2=4.46, P0.05). 4 and 2 cases of adverse reaction were appeared in observation group and control group respectivety during treatment with light symptom. There were no obvious different of adverse reaction in two groups(χ2=0.18,P0.05). Conclusion Bifid Triple Viable Capsules has favorable curative effect and better safety on patients with liver cirrhosis SBP, which can reduce the serum hs-CRP and TNF-α levels and inhibit the local inflammatory process.