2010•PubMedRequires access

[Expression of Mta-1 and VEGF and their correlation in the endometrial cancer].

Yi-min Yang, Hua Liu, Wenbin Li

Abstract

AIM: To explore the expression of metastasis-associated protein 1(Mta-1) and vascular endothelial growth factor (VEGF) and their correlation in the endometrial cancer. METHODS: In 62 cases of endometrial cancer and 30 cases of normal endomedium, the expression of Mta-1 and VEGF was examined with immunohistochemistry and their correlation with pathological phenotype of the endometrial cancer was analyzed. RESULTS: The expression of Mta-1 and VEGF in endometrial cancer was higher than that in normal endomedium (P<0.01). The expression of Mta-1 and VEGF in endometrial cancer was related to clinical stage, pathologic type, lymph node metastasis and depth of myometrial invasion (P<0.05 or P<0.01). Positive correlation was observed between VEGF and Mta-1 expression(r=0.582, P<0.05). CONCLUSION: Expression of Mta-1 expression and VEGF is positively associated with the development and progression of endometrial cancer.

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Key concepts: Endometrial cancer, Immunohistochemistry, Vascular endothelial growth factor, Lymph node metastasis, Pathological, VEGF receptors, Medicine, Metastasis