The changes of serum heart-type fatty acid-binding protein and its clinical significance in children with Kawasaki disease

Objective To study the serum level of heart-type fatty acid-binding protein(h-FABP) in children with Kawasaki disease(KD) and the correlation between it and the ejection fraction(LVEF).Methods The serum levels of h-FABP were determined in the children with KD(n=40) by enzyme-linked immnoabsorbent assay,and the internal diameter of coronary artery and LVEF were measured by two-dimensional echocardiography.Results The h-FABP concentration in KD group at the acute stage was higher than that at the recovery stage(P0.01).The difference of the h-FABP concentration between CAL and NCAL groups was significant(P0.01).The h-FABP concentration in KD group had negative correlation with LVEF(r=-0.35,P0.05).Conclusion The serum concentration of h-FABP is closely related to the severity of myocardial damage in the children with KD.