Efficacy of adefovir dipivoxil(ADV)on patients with chronic hepatitis B and factors of predict efficacy

Objective To investigate the efficiency of on patients with hepatitis B and evaluate the factors of can predict the efficacy. Methods The virology,serology and biochemical indicators of 50 patients who received adefovir dipivoxil for the treatment of chronic hepatitis B were detected and analysised before and at week 12,24 and 48 of the treatment,in order to get the predict efficacy factors of the treatment. Results After 48 weeks of treatment,HBV DNA negative rate was 72.00%,HBeAg seroconvert sion rate was 23.53%,ALT normolization rate was 74.00%,and drug resistant rate was 0,HBV DNA negative rate of HBeAg-negative group was significantly higher than of HBeAg-positive group(P0.05),The rates of HBV DNA negative rate of HBeAg-negative and HBeAg s evaluate eroconversion in patients with base ALT5 ULN were significantly higher than those in patients with 2~5 ULN(P0.05);The rates of HBV DNA negative,ALT normalization and HBeAg seroconversion at week 48 after treatment in patients with HBV DNA negative at week 24 were significantly higher(P0.05).In the course no case stopping treatment for severe adverse effect. Conlusion Adefovir dipivoxil can inhibit HBV DNA replicat ion,normalize ALT and promote HbeAg seroconversion,morever the rate of drug resistance is low.It is a safe and effective antiviral drug.