Correlation between Single Nucleotide Polymorphisms in the Promoter Region of Angiotensinogen Gene and Myocardial Infarction

Aim To evaluate the correlation between three single nucleotide polymorphisms (SNPs) at -217,-20 and -6 locus in the promoter region of angiotensinogen (AGT) gene and myocardial infarction (MI) in south Han Chinese population. Methods ABI PRISM SNaPshot Multiplex Kit was used to genotyping G-217A, A-20C and G-6A polymorphisms in 216 patients with MI and 185 healthy controls. Results The AA, AG and GG genotypes of G-217A polymorphism were obviously different between group of MI and group of controls (10, 77 and 129 to 8, 37 and 140, P=0.002 ). Frequencies of A and G alleles were also significantly different between two groups (22.45%, 77.55% to 14.32%, 85.68%, P=0.003). The AA, AG and GG genotypes of G-6A polymorphism were obviously different between two groups (147, 64 and 5 to 127, 44 and 14, P=0.029). But, frequencies of A and G alleles of G-6A had no significant difference between two groups (P=0.394). The CC, AC and AA genotypes of A-20C polymorphism were different between two groups (6, 51 and 159 to 2, 61 and 122), but no statistical difference was found (P=0.067). Logistic regression analysis showed that age (P=0.001), systolic blood pressure (SBP) (P=0.013) and serum concentration of triglyceride (TG) (P=0.010) were all independent risk factors for MI. Serum concentration of high density lipoprotein-cholesterol (HDLC) (P=0.018) was a protective factor for MI. Conclusions G-217A and G-6A polymorphisms of AGT gene might be associated with the occurrence of myocardial infarction in south Han Chinese population.