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2007•Journal of Apoplexy and Nervous DiseasesRequires access

The change of plasma urokinase-type plasminogen activator and its receptor in patients with intracerebral hemorrhage

Guo Xiu-feng

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Abstract

Objective To investigate the changes of the plasma urokinase-type plasminogen activator (uPA) and urokinase-type plasminogen activator receptor (uPAR) in patients with intracerebral hemorrhage and it's clinical significance.Methods The plasma level of uPA and uPAR were measured by sandwich ELISA in 64 patients with intracerebral hemorrhage and 30 normal healthy subjects.Results Compared with uPA (1075±244ng/L) and uPAR(877±216ng/L) in healthy control group, patients with intracerebral hemorrhage had higher levels of uPA(2866±788ng/L)and uPAR(3645±322ng/L),and there were distinctly difference(P0.01).The severer the patient's degrees was,the higher uPA and uPAR were.Conclusions The increase of uPA and uPAR level is associated with brain injury after intracerebral hemorrhage.The uPA and uPAR level is helpful to evaluate the severity of the patients with intracerebral hemorrhage.

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Objective To investigate the changes of the plasma urokinase-type plasminogen activator (uPA) and urokinase-type plasminogen activator receptor (uPAR) in patients with intracerebral hemorrhage and it's clinical significance.Methods The plasma level of uPA and uPAR were measured by sandwich ELISA in 64 patients with intracerebral hemorrhage and 30 normal healthy subjects.Results Compared with uPA (1075±244ng/L) and uPAR(877±216ng/L) in healthy control group, patients with intracerebral hemorrhage had higher levels of uPA(2866±788ng/L)and uPAR(3645±322ng/L),and there were distinctly difference(P0.01).The severer the patient's degrees was,the higher uPA and uPAR were.Conclusions The increase of uPA and uPAR level is associated with brain injury after intracerebral hemorrhage.The uPA and uPAR level is helpful to evaluate the severity of the patients with intracerebral hemorrhage.

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Available abstract

Objective To investigate the changes of the plasma urokinase-type plasminogen activator (uPA) and urokinase-type plasminogen activator receptor (uPAR) in patients with intracerebral hemorrhage and it's clinical significance.Methods The plasma level of uPA and uPAR were measured by sandwich ELISA in 64 patients with intracerebral hemorrhage and 30 normal healthy subjects.Results Compared with uPA (1075±244ng/L) and uPAR(877±216ng/L) in healthy control group, patients with intracerebral hemorrhage had higher levels of uPA(2866±788ng/L)and uPAR(3645±322ng/L),and there were distinctly difference(P0.01).The severer the patient's degrees was,the higher uPA and uPAR were.Conclusions The increase of uPA and uPAR level is associated with brain injury after intracerebral hemorrhage.The uPA and uPAR level is helpful to evaluate the severity of the patients with intracerebral hemorrhage.

Key concepts: Urokinase receptor, Intracerebral hemorrhage, Plasminogen activator, Urokinase, Medicine, Receptor, Internal medicine, SuPAR

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The change of plasma urokinase-type plasminogen activator and its receptor in patients with intracerebral hemorrhage — Research Paper | ScholarLens