2006•Zhonghua neifenmi daixie zazhiRequires access

Changes of gene expressions of adiponectin in adipose tissue and adiponectin receptor R1 in skeletal muscle of type 2 diabetic rats

Zhi Xia

Abstract

The mRNA levels of adiponectin in adipose tissue and adiponectin receptor R1 in skeletal muscle of type 2 diabetic rats were examined by semi-quatitative RT-PCR.The expression of adiponectin receptor R1 was not altered in the skeletal muscle of type 2 diabetic rats as compared with normal rats.The serum adiponectin level was decreased in diabetic rats due to the decline of adiponectin mRNA level in adipose tissue and rosiglitazone improved the adiponectin deficiency.

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Key concepts: Adiponectin, Internal medicine, Endocrinology, Adiponectin receptor 1, Adipose tissue, Skeletal muscle, Type 2 diabetes, Receptor