The Role of HER-2 Expression in The Program Selection for Breast Cancer Adjuvant Chemotherapy

Objective To explore the relationship between HER-2 expression and the efficacy of different breast cancer adjuvant chemotherapy for screening of effective chemotherapy.Methods 308 cases ofⅠ-Ⅲ breast cancer patients were adjuvant chemotherapyed with three kinds of programs of anthracycline and(or) taxane,HER-2 expression was detected by immunohistochemistry SP samples,the median follow-up 45.00(13.2 ~ 94.1) months,and analysis the relationship among chemotherapy and pathological features(HER-2 status,hormone receptor status,pathological stage) and the survival rate.Results Overall recurrence rate 22.07%(68/308),the average time to progression 27.58 months.In HER-2 positive patients,disease-free survival in anthracycline chemotherapy groupis DFS(135/191),in taxane group chemotherapyis DFS(15/16),and the difference was significant(x2= 3.938,P0.05);the difference between DFS(35/39) in Anthracycline-taxane combination group and that in anthracycline chemotherapy group was significant(x2 = 6.104,P 0.05).In hormone receptor-positive patients,the difference between DFS(116/165) in anthracycline-chemotherapy group and DFS(19/20) in taxol chemotherapy was significant(x2=5.517,P0.05).In the axillary lymph node-positive patients,the difference of the disease-free survival between DFS(73/113) in anthracycline chemotherapy group and DFS17/19 in taxane chemotherapy was significant(x2=4.638,P0.05);the difference between DFS(36/41) in anthracycline-taxane combination group and that in anthracycline was significant(x2 =7.831,P 0.01).Conclusion Breast cancer patients of HER-2 positive were more sensitive to taxane chemotherapy drug,The efficacy of taxane on the hormone receptor-positive patients is better than that of anthracycline,and the efficacy of taxane and anthracycline on the hormone receptor-negative patients was not significantly different.The efficacy of anthracycline-taxane combined and taxane on lymph node-positive is better than that in anthracycline,and the efficacy of anthracycline and taxane and the combined drugs on lymph node-negative is rather.