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[Protective effects of shenmai injection on DPPH free radical-induced injuries in isolated hearts in rabbits].

Nian‐Sheng Li, Xiao-Ming Xiong, Liying Liu

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Abstract

OBJECTIVE: To examine the protective effects of shenmai injection (SM) on DPPH free radical-induced myocardial injury in isolated hearts in rabbits. METHODS: The isolated rabbit hearts were perfused in a Langendorff model. The left ventricular pressure (LVP), the first derivative of LVP (+dp/dtmax), left ventricular end-diastolic pressure (LVEDP) and heart rate(HR) were recorded. Coronary flow (CF) and creatine Kinase (CK) of coronary issue were measured. RESULTS: Perfusion with DPPH (0.25 mumol/L) for 5 min caused a significant impairment of cardiac function, as shown by a decrease in LVP and +dp/dtmax and an increase in LVEDP as well as the increased release of CK. Pretreatment with shenmai injection (1:320) for 10 min significantly improved the cardiac function and decreased the release of CK. CONCLUSION: Shenmai injection protects against the myocardial injury induced by free radical (DPPH) in isolated rabbit hearts.

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What this paper is about

OBJECTIVE: To examine the protective effects of shenmai injection (SM) on DPPH free radical-induced myocardial injury in isolated hearts in rabbits. METHODS: The isolated rabbit hearts were perfused in a Langendorff model. The left ventricular pressure (LVP), the first derivative of LVP (+dp/dtmax), left ventricular end-diastolic pressure (LVEDP) and heart rate(HR) were recorded. Coronary flow (CF) and creatine Kinase (CK) of coronary issue were measured. RESULTS: Perfusion with DPPH (0.25 mumol/L) for 5 min caused a significant impairment of cardiac function, as shown by a decrease in LVP and +dp/dtmax and an increase in LVEDP as well as the increased release of CK. Pretreatment with shenmai injection (1:320) for 10 min significantly improved the cardiac function and decreased the release of CK. CONCLUSION: Shenmai injection protects against the myocardial injury induced by free radical (DPPH) in isolated rabbit hearts.

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Available abstract

OBJECTIVE: To examine the protective effects of shenmai injection (SM) on DPPH free radical-induced myocardial injury in isolated hearts in rabbits. METHODS: The isolated rabbit hearts were perfused in a Langendorff model. The left ventricular pressure (LVP), the first derivative of LVP (+dp/dtmax), left ventricular end-diastolic pressure (LVEDP) and heart rate(HR) were recorded. Coronary flow (CF) and creatine Kinase (CK) of coronary issue were measured. RESULTS: Perfusion with DPPH (0.25 mumol/L) for 5 min caused a significant impairment of cardiac function, as shown by a decrease in LVP and +dp/dtmax and an increase in LVEDP as well as the increased release of CK. Pretreatment with shenmai injection (1:320) for 10 min significantly improved the cardiac function and decreased the release of CK. CONCLUSION: Shenmai injection protects against the myocardial injury induced by free radical (DPPH) in isolated rabbit hearts.

Key concepts: Preload, Ventricular pressure, Cardiology, Medicine, Perfusion, Cardiac function curve, Creatine kinase, Creatine

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[Protective effects of shenmai injection on DPPH free radical-induced injuries in isolated hearts in rabbits]. — Research Paper | ScholarLens