Effect comparison of different doses of aspirin in the treatment for acute cerebral infarction

Objective To investigate the clinical effect of different doses of aspirin in the treatment for acute cerebral infarction. Methods One hundred and twenty-six patients with acute cerebral infarction were selected in the hospital from January 2011 to August 2012, who were randomly divided into two groups. 63 patients fasting oral low-dose aspirin (100 mg/time, 1 time/d, course of 4 weeks) in the morning as the control group. 63 patients fasting oral high-dose aspirin (300 mg/time, 1time/d, course of 4 weeks) in the morning as the observation group. Clinical indicator, clinical effect, neural function defect score, adverse reaction were compared between two groups. Results After treatment, C reactive protein concentration and neural function defect score in the control group and observation group were significantly decreased. C reactive protein concentration and neural function defect score in the observation group were significantly lower than that of the control group. The difference was statistically significant (P 0.05). Total effective rate in the observation group (71.4%) was higher than the control group (60.3%). The incidence of adverse reactions in the observation group (7.9%) was higher than the control group (4.8%). The differences were not statistically significant (P 0.05). Conclusion In the treatment of acute cerebral infarction, effect of high-dose aspirin (300 mg/d) is better than the low-dose (100 mg/d ). Clinical indicators can be improved evidently, and there are no serious adverse reactions. It is worthy of clinical use.