2012•Unpublished venueRequires access
Research on influence of Etanercept on experimental rats with diabetes and periodontitis
Zhao Yu-hon
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Abstract
Objective To study the effects of tumor necrosis factora(TNF-α)inhibitor Etanercept on experimental rats with diabetes and periodontitis.Methods Inject STZ to 45 12-week-old wistar rats to induce diabetics.Ligature teeth neck of diabetics rats to establish periodontitis model.Divide the experimental diabetic rats into the diabetes group,diabetes periodontitis group and diabetes periodontitis +Etanercept group.Observe the gingival index,periodontal pocket and loose degree of rats.Observe the expression of IL- 1β、IL-6 in periodontal tissues by immunohistochemistry.Results There were difference in the gingival index,periodontal pocket and loose degree among the diabetes group,diabetes periodontitis group and diabetes periodontitis+Etanercept group(P0.05);there were difference in the gingival index,periodontal pocket and loose degrees between diabetes periodontitis group and diabetes periodontitis +Etanercept group(P0.05).In diabetes periodontitis group,IL-1β、IL-6 expressed significantly higher than those in diabetes group(P0.05).In diabetes periodontitis+Etanercept group,IL-1β、IL-6 always expressed less than those in diabetes periodontitis group(P0.05).Conclusions TNF-αinhibitor Etanercept can suppress periodontitis of experimental wistar rats with diabetes.