Comparison of clinical effects between insulin detemir and insulin glargine treatment in type 2 diabetes patients

Objective To compare the clinical effects between insulin detemir and insulin glargine treatment in T2DM patients. Methods 70cases of poor blood sugar control of T2DM patients were divided into insulin detemir and glargine groups.At 24weeks of the study,the measured parameters before and after treatment included HbA1 c,FPG,pre-dinner plasma glucose(PDPG),insulin doses, weight gain and the incidence of hypoglycemia. Results HbA1 c and FPG were decreased after 24weeks of treatment(P0.01),but there was no significant difference between two groups.PDPG were significantly decreased both between two groups and intra-groups(P0.01).The doses of insulin were lower in glargine group than in detemir group(P0.05).Average weight gain was lower in detemir group than in glargine group(P0.05).Risk of hypoglycemia was 8.69and 8.92event/(patient·y)in detemir and glargine groups respectively. Conclusion Insulin detemir daily joint short-acting insulin is effective for the treatment of poor glycemic control patients with T2DM.