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2003•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access

Study on the Bioavailability of Genistein Capsule in SD Rats

Qing Wang

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Abstract

Aim To investigate the bioavailability of genistein capsule in rats.Methods Concentrations in plasma were determined by high performance liquid chromatography(HPLC).The 3P87 program was used to calculate the pharmacokinetic parameters.Results Genistein’s main pharmacokinetics parameters were as follows:AUC=3.318μg·ml -1 ·h -1 ,MRT=20.335h,C max =0.206 7μg·ml -1 ,t peak =4h.Its bioavailability was 56.49%.Conclusion This study will provide a scientific basis for the quality evaluation and dosage forms reformation of Genistein Capsule.

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What this paper is about

Aim To investigate the bioavailability of genistein capsule in rats.Methods Concentrations in plasma were determined by high performance liquid chromatography(HPLC).The 3P87 program was used to calculate the pharmacokinetic parameters.Results Genistein’s main pharmacokinetics parameters were as follows:AUC=3.318μg·ml -1 ·h -1 ,MRT=20.335h,C max =0.206 7μg·ml -1 ,t peak =4h.Its bioavailability was 56.49%.Conclusion This study will provide a scientific basis for the quality evaluation and dosage forms reformation of Genistein Capsule.

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Available abstract

Aim To investigate the bioavailability of genistein capsule in rats.Methods Concentrations in plasma were determined by high performance liquid chromatography(HPLC).The 3P87 program was used to calculate the pharmacokinetic parameters.Results Genistein’s main pharmacokinetics parameters were as follows:AUC=3.318μg·ml -1 ·h -1 ,MRT=20.335h,C max =0.206 7μg·ml -1 ,t peak =4h.Its bioavailability was 56.49%.Conclusion This study will provide a scientific basis for the quality evaluation and dosage forms reformation of Genistein Capsule.

Key concepts: Bioavailability, Genistein, Capsule, Pharmacokinetics, Chemistry, Chromatography, Plasma concentration, High-performance liquid chromatography

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