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2011•Acta Universitatis Medicinalis NanjingRequires access

The role of selective inhibition of inducible nitric oxide synthase (iNOS) in small-for-size graft

Xuehao Wang

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Abstract

Objective:To study the role of iNOS in small-for-size graft.Methods:A non-arterialized partial liver transplantation model was used.Rats were divided into three groups:control group,small-for-size group,Aminoguanidine(AG) group.The expression of the iNOS mRNA and protein,the level of alanine aminotransferase(ALT) in serum,as well as histology were checked after reperfusion.Results:The expression of the iNOS in AG group was lower than that of the small-for-size group,but the expression of ALT in serum sample was significantly higher than that of the small-for-size group(P 0.05,n = 5).Histology showed necrosis was observed both in the small-for-size group and the AG group.Conclusion:AG can inhibit iNOS in small-for-size graft,but lead to the worse injury.

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What this paper is about

Objective:To study the role of iNOS in small-for-size graft.Methods:A non-arterialized partial liver transplantation model was used.Rats were divided into three groups:control group,small-for-size group,Aminoguanidine(AG) group.The expression of the iNOS mRNA and protein,the level of alanine aminotransferase(ALT) in serum,as well as histology were checked after reperfusion.Results:The expression of the iNOS in AG group was lower than that of the small-for-size group,but the expression of ALT in serum sample was significantly higher than that of the small-for-size group(P 0.05,n = 5).Histology showed necrosis was observed both in the small-for-size group and the AG group.Conclusion:AG can inhibit iNOS in small-for-size graft,but lead to the worse injury.

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Available abstract

Objective:To study the role of iNOS in small-for-size graft.Methods:A non-arterialized partial liver transplantation model was used.Rats were divided into three groups:control group,small-for-size group,Aminoguanidine(AG) group.The expression of the iNOS mRNA and protein,the level of alanine aminotransferase(ALT) in serum,as well as histology were checked after reperfusion.Results:The expression of the iNOS in AG group was lower than that of the small-for-size group,but the expression of ALT in serum sample was significantly higher than that of the small-for-size group(P 0.05,n = 5).Histology showed necrosis was observed both in the small-for-size group and the AG group.Conclusion:AG can inhibit iNOS in small-for-size graft,but lead to the worse injury.

Key concepts: Nitric oxide synthase, Histology, Alanine aminotransferase, Nitric oxide, Internal medicine, Transplantation, Necrosis, Chemistry

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