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2006•Jishengchong yu yixue kunchong xuebaoRequires access

STUDY ON EXPRESSION OF B7.1,B7.2,IFN-γ,TGF-β GENES OF RAT INFECTED WITH PLASMODIUM YOELII

Xi Zhang

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Abstract

We established an animal model of Plasmodium yoelii-Anopheles stephensi-mammal for the following experiments.In 2 h,12 h,24 h,48 h,72 h,the total RNA of liver and macrophagus from rat infected by Plasmodium yoelii sporozoites were extracted.Then we quantitatively analyzed the expression of B7.1,B7.2,IFN-γ,TGF-β mRNA by RT-PCR.The result indicated that the transcription of B7.2,IFN-γ,TGF-β of rat infected with Plasmodium yoelii sporozoites were up-regulated,while B7.1 remained steadily.The changes of B7.2,TGF-β,IFN-γ mRNA expression suggested these genes were likely involved in the mammal host immune system and related regulations after the rat was infected by Plasmodium yoelii sporozoites.

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What this paper is about

We established an animal model of Plasmodium yoelii-Anopheles stephensi-mammal for the following experiments.In 2 h,12 h,24 h,48 h,72 h,the total RNA of liver and macrophagus from rat infected by Plasmodium yoelii sporozoites were extracted.Then we quantitatively analyzed the expression of B7.1,B7.2,IFN-γ,TGF-β mRNA by RT-PCR.The result indicated that the transcription of B7.2,IFN-γ,TGF-β of rat infected with Plasmodium yoelii sporozoites were up-regulated,while B7.1 remained steadily.The changes of B7.2,TGF-β,IFN-γ mRNA expression suggested these genes were likely involved in the mammal host immune system and related regulations after the rat was infected by Plasmodium yoelii sporozoites.

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Available abstract

We established an animal model of Plasmodium yoelii-Anopheles stephensi-mammal for the following experiments.In 2 h,12 h,24 h,48 h,72 h,the total RNA of liver and macrophagus from rat infected by Plasmodium yoelii sporozoites were extracted.Then we quantitatively analyzed the expression of B7.1,B7.2,IFN-γ,TGF-β mRNA by RT-PCR.The result indicated that the transcription of B7.2,IFN-γ,TGF-β of rat infected with Plasmodium yoelii sporozoites were up-regulated,while B7.1 remained steadily.The changes of B7.2,TGF-β,IFN-γ mRNA expression suggested these genes were likely involved in the mammal host immune system and related regulations after the rat was infected by Plasmodium yoelii sporozoites.

Key concepts: Plasmodium yoelii, Anopheles stephensi, Biology, Plasmodium (life cycle), Gene, Messenger RNA, Immune system, Gene expression

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STUDY ON EXPRESSION OF B7.1,B7.2,IFN-γ,TGF-β GENES OF RAT INFECTED WITH PLASMODIUM YOELII — Research Paper | ScholarLens