Distribution and antibiotic resistance analysis of producing extended-spectrum β-lactamase producing strains in hospitalized children

Objective To investigate the distribution of production of extended spectrum β-lactamases(ESBLs) in the pediatric inpatient strains and drug resistance.Methods ESBLs positive bacterial infections in hospitalized children admitted to hospital in 2008 to 2011,were analyzed retrospectively,using automatic bacterial identification / susceptibility analyzers isolated from Escherichia coli and Klebsiella pneumoniae Peter bacilli testing.Results A total of Gram-negative bacilli 695,a total of 295 ESBLs positive strains,the detection rate of 42.45%(295/695).Escherichia coli 230 ESBLs-producing strains of 114,accounting for 49.57%;Klebsiella pneumoniae 261,181 ESBLs-producing strains,accounting for 69.35%.ESBLs positive bacteria different antibiotic resistance rate and sensitivity rate,the difference was statistically significant(P0.01,P0.05).Conclusions ESBLs positive bacteria has become more important in the pediatric inpatient children with drug-resistant strains,resistance to antimicrobial drugs was significantly higher than non-ESBLs bacteria ESBLs producing bacteria to multiple antimicrobial agents,in addition to imipenem,varying degrees of resistance.Its choice of antibiotic therapy should be based on susceptibility testing results.