Effects of Continuous Infusing Dexmedetomidine on Cardiovascular Response to Endotrachael Intubation of Patients Undergoing General Anesthesia

Objective To observe the effects of continuous infusion of dexmedetomidine on cardiovascular response to endotrachael intubation of patients underwent surgery with general anesthesia.Methods Forty patients,ASA classⅠor Ⅱ,undergoing elective surgery with general anesthesia were randomly divided into control group(D)and dexmedetomidine group(Y).Before the induction,patients in group D received continuous infusion of N.S(20 mL),those patients in group Y for dexmedetomidine 0.5 μg/kg(dissolved by N.S to 20 mL),and the continuous infusion finished in 10 min.All patients got the same anesthetics for induction.The parameters of systolic blood pressure(SBP),diastolic pressure(DBP),mean arterial pressure(MAP),heart rate(HR)of every patient were recorded at the following moment: initial the dexmedetomidine or N.S infusion(foundation values),five and 10 min after infusion;intubation immediately,1 min,2min,5 min,10 min and 15 min after intubation.Results After continuous infusion of N.S or dexmedetomidine,parameters of SBP,DBP,MAP and HR of all patients decreased,especially the HR of patients in group Y(P0.05)at the moment of dexmedetomidine infusion was finished.During tracheal intubation,the SBP,DBP,MAP and HR of patients in group D were significantly higher than foundation values and those of patients in group Y(P0.05).But at this time,these parameters in group Y were similar to their initial values.From the end of tracheal intubation even to 15 min,parameters of SBP,DBP,MAP and HR of patients in both two groups were decreased to the foundation values,particularly at 10min and 15 min after intubation(P0.05)respectively,but there was no difference between two groups.Conclusion Continuous infusion of dexmedetomidine could well control the cardioascular response to tracheal intubation of patiens undergoing general anesthesia during surgery procedures.