The clinical efficacy of lisinopril in treatment of hypertension

Objectives:To study the clinical efficacy and safety of lisinopril in treatment of hypertension.Methods:A single blind experiment was conducted in 108 patients with mild to moderate hypertension.After 2 weeks'placebo treatment ,they were randomly to receive either once daily dose of 10 mg lisinopril(Listril)( n =75),or of 37.5 mg captopril( n =33) for 6 weeks.The dose of the former may be increased 10 to 30 mg every 2 weeks if needed and the dose of the latter may be incresed to 75～ 112.5 mg every 2 weeks if needed.Results:The total effective rate for the active group was 90.7% vs 90.9% for the control group.The most common side effect was cough with an incidence rate of 14.7% for the active vs 15.5% for the control.The 24 h ambulatory BP monitoring was conducted in 28 patients in the active group with a trough peak ratio of 56.8% for SBP and 61.4% for DBP.24 cases of echocardiographic measurement showed that the left ventricular inner diameter and cardiac function were obviously improved.Conclusions:Lisinopril is a long acting agent for mild to moderate hypertension,and a stable and persistant effect may be obtained after a single daily dose. [