2004•Unpublished venueRequires access
Pharmacokinetics and relative bioavailability of nifedipine sustained release pellets
Ma Ping
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Abstract
Objective:To study the pharmacokinetics and relative bioavailability of nifedipine sustained release pellets. Methods: The plasma concentration of nifedipine was determined by HPLC. The data was processed with the software 3P87. Results: The parameters of the two formulations for nifedipine: T max of the pellets and tablets were 3.47 and 5.41 h;C max were 25.7 and 20.2 ng/mL;and AUC 0～∞ were 216 and 168 mg·h·mL -1 respectively. The bioavailability of nifidipine sustained pellets with reference to nifedipine controlled-release tablets is 129%. Conclusions: The results of single oral administration 30 mg nifidipine demonstrated that two formulations were not bioequivalent.