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2006•Shengming kexueRequires access

Telomere binding protein TRF2

Yong Zhang

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Abstract

TRF2 (TTAGGG repeat binding factor-2) is a telomere-related protein. Dimerized TRF2 proteins bind to the telomere repeat squence TTAGGG via their Myb motif. TRF2, TRF1, Rap1, TTN2, TINT1 as well as POT1 assemble a protein complex called shelterin and cooperate to play key roles in maintaining the homeostasis of telomeres. TRF2 not only functions on modeling telomere morphology, controlling telomere length and protecting 3' G-rich overhang, but also regulates the stability of genome. Beyond telomere, TRF2 could be involved in DNA damage response system when telomeric or non-telomeric DNA damage occurrs in cells.

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What this paper is about

TRF2 (TTAGGG repeat binding factor-2) is a telomere-related protein. Dimerized TRF2 proteins bind to the telomere repeat squence TTAGGG via their Myb motif. TRF2, TRF1, Rap1, TTN2, TINT1 as well as POT1 assemble a protein complex called shelterin and cooperate to play key roles in maintaining the homeostasis of telomeres. TRF2 not only functions on modeling telomere morphology, controlling telomere length and protecting 3' G-rich overhang, but also regulates the stability of genome. Beyond telomere, TRF2 could be involved in DNA damage response system when telomeric or non-telomeric DNA damage occurrs in cells.

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Available abstract

TRF2 (TTAGGG repeat binding factor-2) is a telomere-related protein. Dimerized TRF2 proteins bind to the telomere repeat squence TTAGGG via their Myb motif. TRF2, TRF1, Rap1, TTN2, TINT1 as well as POT1 assemble a protein complex called shelterin and cooperate to play key roles in maintaining the homeostasis of telomeres. TRF2 not only functions on modeling telomere morphology, controlling telomere length and protecting 3' G-rich overhang, but also regulates the stability of genome. Beyond telomere, TRF2 could be involved in DNA damage response system when telomeric or non-telomeric DNA damage occurrs in cells.

Key concepts: Shelterin, Telomere, Telomere-binding protein, Rap1, Biology, MYB, Cell biology, DNA

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