Imiquimod cream in treatment of condylomata acuminata:randomized,double-blind controlled clinical trial

AIM: To evaluate the efficacy and safety of 5 % imiquimod cream in the treatment of external condylomata acuminata. METHODS: A randomized, double-blind and controlled clinical trial was employed.5 % imiquimod cream and 2.5 % fluorouracil cream was applied to all external warts three times weekly for 8 wk. Patients who experienced total clearance of the disease were evaluated and followed up for recurrence to 12 wk.RESULTS:Thirty patients with condyloma cuminatum were enrolled in the group A and other 30 patients for the group B. After 8 wk treatment, the number and area of the warts were significantly reduced by compariny with the baseline in both groups(P0.05), and the total efficacy rates was 100 % in the group A and 93 % in the group B. The cure rate was 93 % in each of the two groups. There was no significant difference in efficacy and cure rate between the two groups(P 0.05). The recurrence rates in the group A and group B were 21 % and 39 % respectively, with statistically significant difference for the two groups (P0.05). Local slight adverse reaction rate was 37 % in each of the groups including transient erythma and burn feeling. CONCLUSION:5 % imiquimod cream is an effective, safety preparation for treatment of condyloma acuminatum with relative low recurrence rate.