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1998•Chinese Journal of New Drugs and Clinical RemediesRequires access

Fluoxetine vs amitriptyline in treatment of poststroke depression

Wen Li, Zhi Chen, Shan Bao

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Abstract

AIM: To evaluate the efficacy and safety of domestic fluoxetine in treating poststroke depression (PSD). METHODS: Patients with PSD(n=127) were randomly divided into 2 groups. Fluoxetine group (M 43, F 20, age 60±s 9 a) was treated with fluoxetine 20_40 mg/d, po, for 6 wk. Amitriptyline group (M 45, F 19, age 61±8 a) was treated with amitriptyline 25_50 mg, po, tid for 6 wk. Their symptoms were assessed with Hamilton Depression Scale (HAMD) and Clinical Global Impression (CGI) before and after the treatment. Levels of adverse reaction were determined by Treatment Emergent Symptoms Scale (TESS). RESULTS: Each group reached diminishment on total scores of HAMD(P0.01). The total response rates of fluoxetine and amitriptyline were 92% and 95% respectively(P0.05). Adverse reactions of fluoxetine group were rare and mild(P0.01). CONCLUSION: The domestic fluoxetine has a good efficacy and safety for treatment of PSD.

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AIM: To evaluate the efficacy and safety of domestic fluoxetine in treating poststroke depression (PSD). METHODS: Patients with PSD(n=127) were randomly divided into 2 groups. Fluoxetine group (M 43, F 20, age 60±s 9 a) was treated with fluoxetine 20_40 mg/d, po, for 6 wk. Amitriptyline group (M 45, F 19, age 61±8 a) was treated with amitriptyline 25_50 mg, po, tid for 6 wk. Their symptoms were assessed with Hamilton Depression Scale (HAMD) and Clinical Global Impression (CGI) before and after the treatment. Levels of adverse reaction were determined by Treatment Emergent Symptoms Scale (TESS). RESULTS: Each group reached diminishment on total scores of HAMD(P0.01). The total response rates of fluoxetine and amitriptyline were 92% and 95% respectively(P0.05). Adverse reactions of fluoxetine group were rare and mild(P0.01). CONCLUSION: The domestic fluoxetine has a good efficacy and safety for treatment of PSD.

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Available abstract

AIM: To evaluate the efficacy and safety of domestic fluoxetine in treating poststroke depression (PSD). METHODS: Patients with PSD(n=127) were randomly divided into 2 groups. Fluoxetine group (M 43, F 20, age 60±s 9 a) was treated with fluoxetine 20_40 mg/d, po, for 6 wk. Amitriptyline group (M 45, F 19, age 61±8 a) was treated with amitriptyline 25_50 mg, po, tid for 6 wk. Their symptoms were assessed with Hamilton Depression Scale (HAMD) and Clinical Global Impression (CGI) before and after the treatment. Levels of adverse reaction were determined by Treatment Emergent Symptoms Scale (TESS). RESULTS: Each group reached diminishment on total scores of HAMD(P0.01). The total response rates of fluoxetine and amitriptyline were 92% and 95% respectively(P0.05). Adverse reactions of fluoxetine group were rare and mild(P0.01). CONCLUSION: The domestic fluoxetine has a good efficacy and safety for treatment of PSD.

Key concepts: Fluoxetine, Hamd, Amitriptyline, Clinical Global Impression, Depression (economics), Adverse effect, Hamilton depression scale, Post-stroke depression

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