Synthesis and Performance of PLA/HA Microspheres

Polylactic acid/hydroxyapatite(PLA/HA) composite microspheres were prepared through O/W emulsion/solvent evaporation method by choosing PLA as carrier and HA as core materials.On the basis of ensuring the quality of produced particles,the concentration of emulsifier and other factors were adjusted in a certain range to control the average particle sizes of microspheres after the confirmable factors were fixed.The best crafts to synthesize PLA/HA microspheres with the diameters of about 200μm were found through orthogonal-designed experiment: stirring rate was 500r/min,concentration of PLA was 0.08g/mL,concentration of PVA was 0.006g/mL and adding amounts of HA was 0.10g.SEM showed that the appearance of microspheres was smooth and sphere,but there were some stomas and grooves on the surface;it was found that the degradation speed of PLA/HA microspheres was lower than pure PLA through observation of their degradation behavior in buffer solution;the microspheres having good drug-releasing properties was found by researching drug-releasing rate of PLA/HA microspheres.