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[Role of ICAM-1 in eosinophilia and prognosis of nasal polyps].

Bing Zhou, Huabin Li, De-min Han, Zhongyan Liu

Abstract

OBJECTIVE: To investigate the role of adhesion molecule ICAM-1 (Intercellular adhesion molecule-1) in eosinophilia and prognosis of nasal polyps. METHOD: Expression of ICAM-1 were detected and quantified in 35 cases of nasal polyps with fluorescence-immunohistochemistry analysis and its relationships to eosinophilia and prognosis of nasal polyps were evaluated. RESULT: The numbers of eosinophils in nasal polyps and control nasal mucosas were 28.4 +/- 10.7/mm2 and 9.9 +/- 8.6/mm2, and fluorescent densities of ICAM-1 were 115.9 +/- 82.4 and 28.2 +/- 17.1. The expression of ICAM-1 was associated with the heaviness of nasal polyps. CONCLUSION: ICAM-1 may play an important role in the formation and prognosis of nasal polyps.

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Key concepts: Nasal polyps, Eosinophilia, Immunohistochemistry, Medicine, ICAM-1, Intercellular Adhesion Molecule-1, Pathology, Intercellular adhesion molecule