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2015•China Animal Husbandry & Veterinary MedicineRequires access

Research Progress on Antiviral Effect of MDA5 in Innate Immunity

Liu Huan-hua

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Abstract

Melanoma differentiation-associated gene-5(MDA5)was a nucleic acid receptor in the cytoplasm,in combination with pathogen-associated molecular patterns(PAMPs),which specifically recognized a long double-stranded RNA,function was similar with retinoic acid-inducude geneⅠ(RIG-Ⅰ),after CARD-CARD interaction,it was combinated with the adaptor protein MAVS(also called VISA,Cardif or IPS-1),the interaction might result in the reposition of RLRs in intima,one side it recruited TRAF2/TRAF6 to activate IKK kinase complexes,thereby activating the transcription factor NF-κB;on the other side it recruited TRAF3 and TBK1,thereby promoting phosphorylated activation of IRF3,after activations of the transcription factor NF-κB and IRF,they would enter the nucleus,and work together to promote the expression of typeⅠ interferon gene.

About this research paper

What this paper is about

Melanoma differentiation-associated gene-5(MDA5)was a nucleic acid receptor in the cytoplasm,in combination with pathogen-associated molecular patterns(PAMPs),which specifically recognized a long double-stranded RNA,function was similar with retinoic acid-inducude geneⅠ(RIG-Ⅰ),after CARD-CARD interaction,it was combinated with the adaptor protein MAVS(also called VISA,Cardif or IPS-1),the interaction might result in the reposition of RLRs in intima,one side it recruited TRAF2/TRAF6 to activate IKK kinase complexes,thereby activating the transcription factor NF-κB;on the other side it recruited TRAF3 and TBK1,thereby promoting phosphorylated activation of IRF3,after activations of the transcription factor NF-κB and IRF,they would enter the nucleus,and work together to promote the expression of typeⅠ interferon gene.

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Available abstract

Melanoma differentiation-associated gene-5(MDA5)was a nucleic acid receptor in the cytoplasm,in combination with pathogen-associated molecular patterns(PAMPs),which specifically recognized a long double-stranded RNA,function was similar with retinoic acid-inducude geneⅠ(RIG-Ⅰ),after CARD-CARD interaction,it was combinated with the adaptor protein MAVS(also called VISA,Cardif or IPS-1),the interaction might result in the reposition of RLRs in intima,one side it recruited TRAF2/TRAF6 to activate IKK kinase complexes,thereby activating the transcription factor NF-κB;on the other side it recruited TRAF3 and TBK1,thereby promoting phosphorylated activation of IRF3,after activations of the transcription factor NF-κB and IRF,they would enter the nucleus,and work together to promote the expression of typeⅠ interferon gene.

Key concepts: MDA5, IRF3, TANK-binding kinase 1, Innate immune system, Signal transducing adaptor protein, Transcription factor, RIG-I, Biology

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