Prognostic Value of p53 Expression in Colorectal Cancer at Different Location

Objective To explore the prognostic value of p53 expression in patients with colorectal cancer at different location.Methods p53 protein was detected by immunohistochemistry in tumor tissue specimens from 75 primary colorectal adenocarcinomas.Results Of 75 samples,35(46.7%) had positive expression of p53.p53 overexpression was more frequently existed in distal-located tumor than in proximal-located tumor(59.5% vs.30.3%,P0.05).There was no correlation between p53 expression and other clinicopathologial variables.Median follow-up duration was 60 months.Patients with p53-positive tumors showed a lower overall survival rate than those with p53-negative tumors(P0.05).Furthermore,in patients with distal-located colorectal cancer,p53-positive patients had significantly poor prognosis,compared with p53-negative patients(P0.01),but in patients with proximal-located colon cancer,prognosis was not different(P0.05).Conclusion The overexpression of p53 protein is influenced by the the tumor location.It may provide important prognostic information in distal-located colorectal cancer.