2010•Information on Traditional Chinese MedicineRequires access
The Effect of XinNaoTongLuoYe on the Content of Interleukin -8 and IGF -1 in Brain of Focal Cerebral Ischemia Rats
Xi Chen
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Abstract
Objective: To observe the effect of XinNaoTongLuoYe on the content of interleukin-8 and IGF-1 in brain of focal cerebral ischemia rats.Methods: To make the model of focal cerebral ischemia by inserting nylon thread,compared with Bu Chang Nao Xin Tong,the effect on infarct volume and the content of interleukin -8 and IGF-1in brain of focal cerebral ischemia rats were observed in 6h、12h、24h and 48h after cerebral ischemia.Results: 6h after cerebral ischemia,the content of interleukin-8 in brain increased,and it reached its chemia top in 48h(P 0.01);Compared with model group,the content of IL-8 in brain of each treatment group was decreased except the control group,low-dose group in 6h、12h after cerebralischemia.(P 0.01orP 0.05).in 6h after cerebral ischemia,the content of IGF-1 in brain increased and it reached top in 48h(P 0.01);Compared with model group,the content of IGF-1 in brain of treatment group was increased (P 0.01).Conclusion: XinNaoTongLuoYe can reduce content of IL-8 in cerebral tissue during cerebral ischemia and alleviate the level of inflammation.XinNaoTongLuoYe can increase content of IGF-1 in brain tissue which may be the endogenous protective mechanism during the ischemia situation.