Protective effects of urinary protease inhibitor on the collapsed lungs with one-lung anesthesia

Objective To explore the protective effect of the urinary protease inhibitor on the collapsed lungs with one-lung anesthesia. Methods Thirty ASA Ⅱ-Ⅲ esophageal cancer patients with one-lung ventilation Undergoing open thoracic surgery were randomly divided into 2 groups(n=15 each):control group(group C) and urinary protease inhibitor group(group U).In group U, urinastatin was given total 300000U/100ml in 30 minutes adopting micro pump infusion after anesthesia induction.In group C,saline was given 100ml in 30 minutes. Bronchoalveolar lavage fluid samples were taken With fiberoptic bronchoscopy by lavaging operation side lung before one-lung ventilition(T0,baseline),at 1 hour after one-lung ventilition(T1,), 2 hours after one-lung ventilition(T2)and the end of the surgery(T3). IL-6、IL-8 and TNF-αconcentrations were determined by EASIA methods and neutrophils were counted by using Rayleigh's method.Results Compared with the baseline values at T0,IL-6、IL-8 TNF-αconcentrations and neutrophils counts at T3、T4 were all significantly increased in group C and group U. but the IL-6、IL-8 、TNF-αconcentrations and neutrophils counts were lower in group U than in group C(P0.05).Conclusion Urinary protease inhibitor can protect the collapsed lungs with one-lung anesthesia.