Change of serum immunotoxicology indexes in patients with anaphylaxis induced by Qinkailing Injection: prospective nested case-control study

AIM To determine the relationship between the change of immunotoxicology indexes of serum and the occurrence in patients with anaphylaxis induced by Qingkailing Injection,which was composed of cholic acid,mother-of-pearl,gardenia,cornu bubali,isatis root,baicalin,honeysuckle,and to establish the method of detection of the type of in patients with anaphylaxis induced by traditional Chinese medicine injection.METHODS In a prospective nested case-control study,we compared the concentration of IgE,IgG,IL-4,histamine in eighteen cases with anaphylaxis induced by Qingkailing Injection with those from 72 matched controls who remained normal after using Qingkailing Injection.The correlation between the change of IgE,IgG,IL-4,histamine of serum and the occurrence in patients with anaphylaxis induced by Qingkailing Injection was determined.RESULTS The serum concentrations of IgE,IgG,IL-4,histamine of eighteen cases were significantly higher than those in the controls(P≤0.05).There was the close relationship between the rise of IgE,IgG,IL-4 of serum of test group and the occurrence in patients with anaphylaxis induced by Qingkailing Injection(P0.05),OR is 1.534,21.4,27.552 respectively.CONCLUSION The allergic reaction caused by Qingkailing Injection may be due to typeⅠallergic reaction;IgE,IgG,IL-4,Histamine can serve as clinical evaluation indicators in evaluating the damage to immune system induced by Qingkailing Injection.Cytokines are more likely to become the effective evaluation index in diagnosis of in patients with anaphylaxis induced by herbal injection.