Synthesis and antifungal activities of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substituted-piperazine)-1-yl]-2-propanols

Aim To study the effect of the triazole derivatives with the side chain containing(4-substituted-piperidine)-1-yl or second amine on the antifungal activity of triazole compounds.Methods Nine title compounds were synthesized and determined by the elementary analysis,()~1H-NMR and IR spectra.The MICs of all the title compounds were determined by the method recommended by the national committee for clinical laboratory standards(NCCLS)using the RPMI 1640 test medium.Results All of the title compounds displayed potent antifungal activities to some extent.The activity of the two compounds 4,5 were more than 4 times as high as that of fluconazole and itraconazole against Candida albicans in vitro.Conclusion The stereochemistry has important influence on the antifungal activities of the title compounds.