Experimental Study on Effects of “Hua Xian Fang” on Pulmonary Coefficients and Morphological Changes In Rats of Pulmonary Fibrosis

Objective To investigate the effects of “Hua Xian Fang” on pulmonary fibrosis and pulmonary coefficients in rats induced by bleomycin and explore its mechanism. Methods Healthy SD rats were randomly allocated into 6 groups:normal group,model group,the high-dosage of“Hua Xian Fang” group,the middle-dosage of“Hua Xian Fang” group,the low-dosage of “Hua Xian Fang” group,and the prednisone group. The six groups except for the normal group were injected with bleomycin via trachea to induce experimental pulmonary fibrosis, and lavage respectively with “Hua Xian Fang” at 20 times, 10 times, 5 times of adult-dosage on the 7th day after medication. After a month, all rats were sacrificed and the pulmonary pathological changes and pulmonary coefficient were observed in each group. Results The pulmonary coefficients of the every “Hua Xian Fang” group and the prednisone group compared with the model group were obviously reduced (P 0.01). The histopathological examination markedly reduced alveolitis and pulmonary fibrosis. Conclusion It is revealed that “Hua Xian Fang” has some effects on bleomycin-induced pulmonary fibrosis and smaller side-effect than Prednisone.