2014•Journal of Nanchang UniversityRequires access
Analgesic Effect of Intrathecal Dexmedetomidine on Postoperative Incisional Pain in Rats
Huang Da
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Abstract
Objective To investigate the analgesic effect of intrathecal dexmedetomidine on postoperative incisional pain in rats and its possible mechanism of action.Methods Forty healthy male SD rats were randomly divided into four groups of 10each:sham operation group(groupⅠ):rats received no treatment;incisional pain group(group Ⅱ):rats received left plantar incision;normal saline group(group Ⅲ):rats received left plantar incision after intrathecal injection of normal saline;dexmedetomidine group(group Ⅳ):rats received left plantar incision after intrathecal injection of dexmedetomidine 0.75μg·kg-1.Mechanical withdrawal threshold(MWT),thermal withdrawal latency(TWL)and phosphorylated cAMP response element-binding protein(pCREB)expression in the spinal dorsal horn were observed 2hours after operation.ResultsCompared with group Ⅰ,MWT and TWL decreased and pCREB expression in the spinal dorsal horn increased in groups Ⅱ,Ⅲ and Ⅳ(P0.05).Compared with group Ⅱ or Ⅲ,MWT and TWL increased and pCREB expression in the spinal dorsal horn decreased in groupⅣ(P0.05).Conclusion Intrathecal dexmedetomidine may alleviate incisional pain in rats and the mechanism of action of dexmedetomidine may involve the increase in pCREB expression in spinal dorsal horn.